A stereoselective synthesis of α-deuterium-labelled (S)-α-amino acids
نویسندگان
چکیده
منابع مشابه
Enantioselective synthesis of α-deuterium labelled chiral α-amino acids via dynamic kinetic resolution of racemic azlactones.
Catalytic dynamic kinetic resolution (DKR) of racemic azlactones with EtOD using squaramide-based dimeric cinchona alkaloid organocatalysts is shown to be a highly effective strategy for the preparation of enantiomerically pure α-deuterated chiral α-amino acids.
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α-Fluoro-α-nitro esters were used as reaction partners in Michael addition to nitroalkenes, and the products were obtained in excellent chemical yields and with high enantioselectivities. Moreover, α-fluoro-α-amino ester with a quaternary α-carbon was prepared for the first time.
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2010
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-010-0541-3